TAE™ - Targeted Affinity Enhancement™ is a next-generation affinity maturation technology that creates a comprehensive map of the paratope sequence space to allow identification of beneficial, neutral, and detrimental amino acid substitutions at each CDR position
- TAE™ addresses shortcomings of existing strategies
- Targeted process - no back-mutations required
- Smaller, focused libraries due to efficient codon usage
- No screening or panning required
- Broad utility regardless of antibody source
- Compatible with any phage display library, transgenic mouse and hybridoma monoclonal antibodies
- Pre-selected amino acids for improved manufacturability
- Testing of each antibody variant is performed in a time and cost-effective manner
- Broader IP coverage of antibody sequence space based on comprehensive mutagenesis and testing strategy
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HE™ - Human Engineering
- Unique humanization technology to retain binding affinity and function while reducing immunogenicity potential
- Optimizes biophysical properties of antibodies while maintaining proper folding and preserving antibody function (e.g., antigen binding)
- Provides a robust and systematic methodology based on conserved structure-function relationships between antibody variable regions
- Relies on evolutionary conservation of amino acid residue orientation
- 3-D crystal structure analysis from a diverse set of antibodies
- Systematic approach broadly applicable to all antibodies
- Produces consistent retention of affinity yields, increased confidence of success and accelerated timeline
- No structural modeling required
- No post-humanization adjustments
- Provides an unencumbered IP path
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