XOMA 129 is a highly potent fragment of a monoclonal antibody ("Fab") with negative allosteric modulation activity against the insulin receptor that was derived from the XMetD program.
In animal model testing, XOMA 129 appears to have a fast onset of action and short half-life. This drug candidate profile enables dosing regimens more tailored for certain acute or chronic endogenous and drug-induced hypoglycemias.
Hypoglycemia is a serious medical condition in patients with Type 2 diabetes and Type 1 diabetes and can occur as a result of insulin therapy, accidental insulin overdose or treatment with sulfonylureas. Recurrent hypoglycemia leads to diminished recognition of the symptoms, which include palpitations, tremors, anxiety, sweating, and hunger. This reduced sensitivity to hypoglycemic symptoms can lead to more prolonged episodes and the advancement into acute severe hypoglycemia, which can result in confusion, loss of consciousness, and seizure.
Acute severe hypoglycemia often presents in patients who are treated aggressively for their Type 1 diabetes during the nocturnal hours, which puts them at elevated risk for loss of consciousness and seizure. The medical community has long been challenged with how to prevent patients from experiencing nocturnal severe hypoglycemia, yet there have not been any significant breakthroughs in pharmaceutical development efforts or experiments in dietary practices.